Structure of PDB 2li8 Chain A

Receptor sequence
>2li8A (length=63) Species: 9606 (Homo sapiens) [Search protein sequence]
PKGKSMQKRRSKGDRCYNCGGLDHHAKECKLPPQPKKCHFCQSISHMVAS
CPLKAQQGPSAQG
3D structure
PDB2li8 Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A M129 K131 R132 R133 S134 D137 R138 Y140 H148 A149 K150 K159 K160 C161 H162 M170 V171 A172 M6 K8 R9 R10 S11 D14 R15 Y17 H25 A26 K27 K36 K37 C38 H39 M47 V48 A49 PDBbind-CN: Kd=0.16nM
BS02 ZN A C139 C142 H147 C152 C16 C19 H24 C29
BS03 ZN A C161 C164 H169 C174 C38 C41 H46 C51
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:2li8, PDBe:2li8, PDBj:2li8
PDBsum2li8
PubMed22157959
UniProtQ9H9Z2|LN28A_HUMAN Protein lin-28 homolog A (Gene Name=LIN28A)

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