Structure of PDB 2lec Chain A

Receptor sequence
>2lecA (length=101) Species: 9606 (Homo sapiens) [Search protein sequence]
MSYGRPPPDVEGMTSLKVDNLTYRTSPDTLRRVFEKYGRVGDVYIPRDRY
TKESRGFAFVRFHDKRDAEDAMDAMDGAVLDGRELRVQMARYGRPPDSHH
S
3D structure
PDB2lec A syn-anti conformational difference allows SRSF2 to recognize guanines and cytosines equally well.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A G4 R5 P6 K17 D42 Y44 P46 D48 R49 F57 F59 R61 R91 Y92 G93 R94 P95 S98 H99 G4 R5 P6 K17 D42 Y44 P46 D48 R49 F57 F59 R61 R91 Y92 G93 R94 P95 S98 H99 PDBbind-CN: Kd=0.22uM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

View graph for
Molecular Function
External links
PDB RCSB:2lec, PDBe:2lec, PDBj:2lec
PDBsum2lec
PubMed22002536
UniProtQ01130|SRSF2_HUMAN Serine/arginine-rich splicing factor 2 (Gene Name=SRSF2)

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