Structure of PDB 2lb2 Chain A

Receptor sequence
>2lb2A (length=35) Species: 9606 (Homo sapiens) [Search protein sequence]
GLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQL
3D structure
PDB2lb2 A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
2.3.2.36: RING-type E3 ubiquitin transferase (cysteine targeting).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E372 E373 R374 K378 R380 Y382 V384 N385 H386 R389 T390 T391 W393 E7 E8 R9 K13 R15 Y17 V19 N20 H21 R24 T25 T26 W28
External links
PDB RCSB:2lb2, PDBe:2lb2, PDBj:2lb2
PDBsum2lb2
PubMed21685363
UniProtQ96PU5|NED4L_HUMAN E3 ubiquitin-protein ligase NEDD4-like (Gene Name=NEDD4L)

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