Structure of PDB 2l4l Chain A

Receptor sequence
>2l4lA (length=45) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
KNVKCFNCGKEGHTARNCRAPRKKGCWKCGKEGHQMKDCTERQAN
3D structure
PDB2l4l Structural insights into the cTAR DNA recognition by the HIV-1 nucleocapsid protein: role of sugar deoxyriboses in the binding polarity of NC.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A F16 T24 R26 K33 C36 W37 Q45 M46 F6 T14 R16 K23 C26 W27 Q35 M36 PDBbind-CN: Kd=1.6uM
BS02 ZN A C15 C18 H23 C28 C5 C8 H13 C18
BS03 ZN A C36 C39 H44 C49 C26 C29 H34 C39
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:2l4l, PDBe:2l4l, PDBj:2l4l
PDBsum2l4l
PubMed21227929
UniProtP03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)

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