Structure of PDB 2ksa Chain A

Receptor sequence
>2ksaA (length=363) Species: 9606 (Homo sapiens) [Search protein sequence]
DNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNV
VVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYG
LFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVI
CVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVT
VLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMI
VVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYN
PIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKV
SRLETTISTVVGA
3D structure
PDB2ksa NMR evidence of GM1-induced conformational change of Substance P using isotropic bicelles
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D10 S16 T19 D9 S15 T18
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004995 tachykinin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ksa, PDBe:2ksa, PDBj:2ksa
PDBsum2ksa
PubMed20937248
UniProtP25103|NK1R_HUMAN Substance-P receptor (Gene Name=TACR1)

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