Structure of PDB 2kkf Chain A

Receptor sequence

>2kkfA (length=57) Species: 9606 (Homo sapiens)

KKGRRSRRCGQCPGCQVPEDCGVCTNCLDKPKFGGRNIKKQCCKMRKCQN
LQWMPSK

3D structure

• PDB: 2kkf Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.
• Chain: A
• Resolution: N/A

Enzymatic activity

• Enzyme Commision number: 2.1.1.-
  2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	K1147 R1150 S1152 R1154 N1183 K1186 Q1187 C1188 K1193 L1197	K1 R4 S6 R8 N37 K40 Q41 C42 K47 L51	PDBbind-CN: Kd=44uM
BS02	dna	A	K1147 K1148 R1150 R1151 T1171 I1184 K1185 K1186 K1203	K1 K2 R4 R5 T25 I38 K39 K40 K57	PDBbind-CN: Kd=44uM
BS03	ZN	A	C1155 C1158 C1161 C1194	C9 C12 C15 C48
BS04	ZN	A	C1167 C1170 C1173 C1189	C21 C24 C27 C43

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0008270 zinc ion binding

External links

• PDB: RCSB:2kkf, PDBe:2kkf, PDBj:2kkf
• PDBsum: 2kkf
• PubMed: 20010842
• UniProt: Q03164|KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Gene Name=KMT2A)