Structure of PDB 2k9c Chain A

Receptor sequence
>2k9cA (length=152) Species: 9606 (Homo sapiens) [Search protein sequence]
HYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILV
VFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTN
LFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSL
YG
3D structure
PDB2k9c Paramagnetic shifts in solid-state NMR of proteins to elicit structural information
ChainA
ResolutionN/A
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H218 E219 H222 H228
Catalytic site (residue number reindexed from 1) H107 E108 H111 H117
Enzyme Commision number 3.4.24.65: macrophage elastase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO A H218 H222 H107 H111
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0031012 extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2k9c, PDBe:2k9c, PDBj:2k9c
PDBsum2k9c
PubMed18988744
UniProtP39900|MMP12_HUMAN Macrophage metalloelastase (Gene Name=MMP12)

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