Structure of PDB 2k31 Chain A

Receptor sequence
>2k31A (length=149) Species: 10090 (Mus musculus) [Search protein sequence]
DVTALCHKIFLHIHGLISADRYSLFLVCEDSSKDKFLISRLFDVAEGSTL
EEASNNCIRLEWNKGIVGHVAAFGEPLNIKDAYEDPRFNAEVDQITGYKT
QSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAEYLAFCGE
3D structure
PDB2k31 Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5: Insights into Nucleotide Selectivity, Dimerization, and cGMP-Dependent Conformational Change.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 35G A S176 F178 F195 D196 I211 I219 Y236 F241 N242 V245 T249 I275 S23 F25 F42 D43 I58 I66 Y83 F88 N89 V92 T96 I122 PDBbind-CN: -logKd/Ki=8.70,IC50=2.0nM
External links
PDB RCSB:2k31, PDBe:2k31, PDBj:2k31
PDBsum2k31
PubMed18534985
UniProtQ8CG03|PDE5A_MOUSE cGMP-specific 3',5'-cyclic phosphodiesterase (Gene Name=Pde5a)

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