Structure of PDB 2jlw Chain A

Receptor sequence
>2jlwA (length=450) Species: 408688 (Dengue virus 4 Thailand/0348/1991) [Search protein sequence]
GSAMGEPDYEVDEDIFRKKRLTIMDLHPGAGKTKRILPSIVREALKRRLR
TLILAPTRVVAAEMEEALRGLPIRYQTPAVKSDHTGREIVDLMCHATFTT
RLLSTRVPNYNLIVMDEAHFTDPCSVAARGYISTRVEMGEAAAIFMTATP
PGSIDPFPQSNSPIEDIEREIPERSWNTGFDWITDYQGKTVWFVPSIKAG
NDIANCLRKSGKRVIQLSRKTFDTEYPKTKLTDWDFVVTTDISEMGANFR
AGRVIDPRRCLKPVILTDGPERVILAGPIPVTPASAAQRRGRIGRNPAQE
DDQYVFSGDPLKNDEDHAHWTEAKMLLDNIYTPEGIIPTLFGPEREKTQA
IDGEFRLRGEQRKTFVELMRRGDLPVWLSYKVASAGISYKDREWCFTGER
NNQILEENMEVEIWTREGEKKKLRPKWLDARVYADPMALKDFKEFASGRK
3D structure
PDB2jlw Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A R225 T244 P245 C261 A263 T264 P363 S364 I365 S386 R387 T408 I410 R599 R58 T77 P78 C94 A96 T97 P195 S196 I197 S218 R219 T240 I242 R431
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:2jlw, PDBe:2jlw, PDBj:2jlw
PDBsum2jlw
PubMed19008861
UniProtQ2YHF0|POLG_DEN4T Genome polyprotein

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