Structure of PDB 2jlu Chain A

Receptor sequence
>2jluA (length=451) Species: 408688 (Dengue virus 4 Thailand/0348/1991) [Search protein sequence]
GSAMGEPDYEVDEDIFRKKRLTIMDLHPGAGKTKRILPSIVREALKRRLR
TLILAPTRVVAAEMEEALRGLPIRYQTPAVKSDHTGREIVDLMCHATFTT
RLLSSTRVPNYNLIVMDEAHFTDPCSVAARGYISTRVEMGEAAAIFMTAT
PPGSIDPFPQSNSPIEDIEREIPERSWNTGFDWITDYQGKTVWFVPSIKA
GNDIANCLRKSGKRVIQLSRKTFDTEYPKTKLTDWDFVVTTDISEMGANF
RAGRVIDPRRCLKPVILTDGPERVILAGPIPVTPASAAQRRGRIGRNPAQ
EDDQYVFSGDPLKNDEDHAHWTEAKMLLDNIYTPEGIIPTLFGPEREKTQ
AIDGEFRLRGEQRKTFVELMRRGDLPVWLSYKVASAGISYKDREWCFTGE
RNNQILEENMEVEIWTREGEKKKLRPKWLDARVYADPMALKDFKEFASGR
K
3D structure
PDB2jlu Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein.
ChainA
Resolution2.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A T224 R225 Q243 T244 P245 C261 A263 T264 R268 D290 P363 S364 I365 S386 R387 T408 D409 I410 L429 P431 L443 R599 T57 R58 Q76 T77 P78 C94 A96 T97 R101 D123 P196 S197 I198 S219 R220 T241 D242 I243 L262 P264 L276 R432
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:2jlu, PDBe:2jlu, PDBj:2jlu
PDBsum2jlu
PubMed19008861
UniProtQ2YHF0|POLG_DEN4T Genome polyprotein

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