Structure of PDB 2jlr Chain A

Receptor sequence
>2jlrA (length=439) Species: 408688 (Dengue virus 4 Thailand/0348/1991) [Search protein sequence]
EDIFRKKRLTIMDLHPGAGKTKRILPSIVREALKRRLRTLILAPTRVVAA
EMEEALRGLPIRYQTPAVKSDHTGREIVDLMCHATFTTRLLSSTRVPNYN
LIVMDEAHFTDPCSVAARGYISTRVEMGEAAAIFMTATPPGSTDPFPQSN
SPIEDIEREIPERSWNTGFDWITDYQGKTVWFVPSIKAGNDIANCLRKSG
KRVIQLSRKTFDTEYPKTKLTDWDFVVTTDISEMGANFRAGRVIDPRRCL
KPVILTDGPERVILAGPIPVTPASAAQRRGRIGRNPAQEDDQYVFSGDPL
RNDEDHAHWTEAKMLLDNIYTPEGIIPTLFGPEREKTQAIDGEFRLKGEQ
RKTFVELMRRGDLPVWLSYKVASAGISYKDREWCFTGERNNQILEENMEV
EIWTREGEKKKLRPKWLDARVYADPMALKDFKEFASGRK
3D structure
PDB2jlr Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A T200 E285 T21 E106
BS02 ANP A G196 G198 K199 T200 K201 E285 N416 R460 R463 G17 G19 K20 T21 K22 E106 N237 R281 R284
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:2jlr, PDBe:2jlr, PDBj:2jlr
PDBsum2jlr
PubMed19008861
UniProtQ2YHF0|POLG_DEN4T Genome polyprotein

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