Structure of PDB 2jkb Chain A

Receptor sequence
>2jkbA (length=661) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence]
LSISPIFQGGSYQLNNKSIDISSLLLDKLSGESQTVVMKFKADKPNSLQA
LFGLSNSKAGFKNNYFSIFMRDSGEIGVEIRDAQKGINYLFSRPASLWGK
HKGQAVENTLVFVSDSKDKTYTMYVNGIEVFSETVDTFLPISNINGIDKA
TLGAVNREGKEHYLAKGSIDEISLFNKAISDQEVSTIPLSNPFQLIFQSG
DSTQANYFRIPTLYTLSSGRVLSSIDARYGGTHDSKSKINIATSYSDDNG
KTWSEPIFAMKFNDYEEQLVYWPRDNKLKNSQISGSASFIDSSIVEDKKS
GKTILLADVMPAGIGNNNANKADSGFKEINGHYYLKLKKNGDNDFRYTVR
ENGVVYNETTNKPTNYTINDKYEVLEGGKSLTVEQYSVDFDSGSLRERHN
GKQVPMNVFYKDSLFKVTPTNYIAMTTSQNRGESWEQFKLLPPFLGEKHN
GTYLCPGQGLALKSSNRLIFATYTSGELTYLISDDSGQTWKKSSASIPFK
NATAEAQMVELRDGVIRTFFRTTTGKIAYMTSRDSGETWSKVSYIDGIQQ
TSYGTQVSAIKYSQLIDGKEAVILSTPNSRSGRKGGQLVVGLVNKEDDSI
DWKYHYDIDLPSYGYAYSAITELPNHHIGVLFEKYDSWSRNELHLSNVVQ
YIDLEINDLTK
3D structure
PDB2jkb Structural and Functional Studies of Streptococcus Pneumoniae Neuraminidase B: An Intramolecular Trans-Sialidase.
ChainA
Resolution1.54 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D270 E541 Y653
Catalytic site (residue number reindexed from 1) D234 E505 Y617
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SKD A R245 D270 I326 D327 N352 T539 R557 R619 Y653 R209 D234 I290 D291 N316 T503 R521 R583 Y617
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006689 ganglioside catabolic process
GO:0009313 oligosaccharide catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2jkb, PDBe:2jkb, PDBj:2jkb
PDBsum2jkb
PubMed18775704
UniProtQ54727|NANB_STRPN Sialidase B (Gene Name=nanB)

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