Structure of PDB 2jj3 Chain A

Receptor sequence
>2jj3A (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]
DALSPEQLVLTLLEAEPPHVLISRPASMMMSLTKLADKELVHMISWAKKI
PGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDE
GKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVSS
RKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGM
EHLLNMKNVVPVYDLLLEMLNAH
3D structure
PDB2jj3 Benzopyrans as Selective Estrogen Receptor Beta Agonists (Serbas). Part 4: Functionalization of the Benzopyran A-Ring.
ChainA
Resolution2.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JJ3 A M295 L298 T299 A302 E305 L339 F356 H475 L476 V487 M29 L32 T33 A36 E39 L73 F90 H202 L203 V212 MOAD: Ki=0.28nM
PDBbind-CN: -logKd/Ki=9.55,Ki=0.28nM
BindingDB: Ki=0.28nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:2jj3, PDBe:2jj3, PDBj:2jj3
PDBsum2jj3
PubMed17662603
UniProtQ92731|ESR2_HUMAN Estrogen receptor beta (Gene Name=ESR2)

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