Structure of PDB 2jis Chain A

Receptor sequence
>2jisA (length=478) Species: 9606 (Homo sapiens) [Search protein sequence]
LPSLAGDPVAVEALLRAVFGVVVDEAIQKGTSVSQKVCEWKEPEELKQLL
DLELRSQGESQKQILERCRAVIRYSVKTGHPRFFNQLFSGLDPHALAGRI
ITESLNTSQYTYEIAPVFVLMEEEVLRKLRALVGWSSGDGIFCPGGSISN
MYAVNLARYQRYPDCKQRGLRTLPPLALFTSKECHYSIQKGAAFLGLGTD
SVRVVKADERGKMVPEDLERQIGMAEAEGAVPFLVSATSGTTVLGAFDPL
EAIADVCQRHGLWLHVDAAWGGSVLLSQTHRHLLDGIQRADSVAWNPHKL
LAAGLQCSALLLQDTSNLLKRCHGSKFYDVALDTGDKVVQCGRRVDCLKL
WLMWKAQGDQGLERRIDQAFVLARYLVEEMKKREGFELVMEPEFVNVCFW
FVPPSLRGKQESPDYHERLSKVAPVLKERMVKEGSMMIGYQPHGTRGNFF
RVVVANSALTCADMDFLLNELERLGQDL
3D structure
PDB2jis The Crystal Structure of Human Cysteine Sulfinic Acid Decarboxylase (Csad)
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.11: aspartate 1-decarboxylase.
4.1.1.29: sulfinoalanine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A G151 G152 S153 H191 T248 D273 A275 N302 K305 G145 G146 S147 H185 T242 D267 A269 N296 K299
BS02 PLP A C356 G357 C341 G342
Gene Ontology
Molecular Function
GO:0004068 aspartate 1-decarboxylase activity
GO:0004782 sulfinoalanine decarboxylase activity
GO:0016830 carbon-carbon lyase activity
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0019449 L-cysteine catabolic process to hypotaurine
GO:0019452 L-cysteine catabolic process to taurine
GO:0019752 carboxylic acid metabolic process
GO:0042412 taurine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:2jis, PDBe:2jis, PDBj:2jis
PDBsum2jis
PubMed
UniProtQ9Y600|CSAD_HUMAN Cysteine sulfinic acid decarboxylase (Gene Name=CSAD)

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