Structure of PDB 2jfa Chain A

Receptor sequence
>2jfaA (length=221) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYPFSEASMMGLLTNLADRELVHMI
NWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNL
LLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGV
YTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLL
LILSHIRHMSNKGMEHLYSMK
3D structure
PDB2jfa Structural Insights Into Corepressor Recognition by Antagonist-Bound Estrogen Receptors.
ChainA
Resolution2.55 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L354 I358 K362 L372 Q375 E380 L46 I50 K54 L64 Q67 E72
BS02 RAL A L346 T347 A350 D351 E353 L354 W383 L387 F404 M421 I424 H524 L38 T39 A42 D43 E45 L46 W75 L79 F96 M113 I116 H216 BindingDB: IC50=1.8nM,EC50=2.4nM,Ki=0.37nM
External links
PDB RCSB:2jfa, PDBe:2jfa, PDBj:2jfa
PDBsum2jfa
PubMed17283072
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

[Back to BioLiP]