Structure of PDB 2jf9 Chain A

Receptor sequence
>2jf9A (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSH
IRHMSNKGMEHLYSM
3D structure
PDB2jf9 Structural Insights Into Corepressor Recognition by Antagonist-Bound Estrogen Receptors.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D351 L354 I358 L372 V376 L379 E380 W383 D47 L50 I54 L68 V72 L75 E76 W79
BS02 peptide A D332 T334 D28 T30
BS03 OHT A M343 T347 A350 D351 E353 W383 F404 M421 L525 M39 T43 A46 D47 E49 W79 F100 M117 L212 BindingDB: IC50=0.790000nM,EC50=10.3nM,Ki=5.7nM
BS04 BCT A L327 R352 L23 R48
External links
PDB RCSB:2jf9, PDBe:2jf9, PDBj:2jf9
PDBsum2jf9
PubMed17283072
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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