Structure of PDB 2jew Chain A

Receptor sequence
>2jewA (length=304) Species: 9823 (Sus scrofa) [Search protein sequence]
GHSYEKYNNWETIEAWTKQVTSENPDLISRTAIGTTFLGNNIYLLKVGKP
GPNKPAIFMDCGFHAREWISHAFCQWFVREAVLTYGYESHMTEFLNKLDF
YVLPVLNIDGYIYTWTKNRMWRKTRSTNAGTTCIGTDPNRNFDAGWCTTG
ASTDPCDETYCGSAAESEKETKALADFIRNNLSSIKAYLTIHSYSQMILY
PYSYDYKLPENNAELNNLAKAAVKELATLYGTKYTYGPGATTIYPAAGGS
DDWAYDQGIKYSFTFELRDKGRYGFILPESQIQATCEETMLAIKYVTNYV
LGHL
3D structure
PDB2jew Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis.
ChainA
Resolution1.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H69 E72 R127 H196 E270
Catalytic site (residue number reindexed from 1) H64 E67 R122 H192 E266
Enzyme Commision number 3.4.17.2: carboxypeptidase B.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A E85 E291 E80 E287
BS02 ZN A H69 E72 H196 H64 E67 H192
BS03 720 A E72 N144 R145 H196 Y198 D255 E270 E67 N139 R140 H192 Y194 D251 E266 MOAD: Ki=206nM
PDBbind-CN: -logKd/Ki=6.69,Ki=206nM
BindingDB: Ki=206nM
Gene Ontology
Molecular Function
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2jew, PDBe:2jew, PDBj:2jew
PDBsum2jew
PubMed17990866
UniProtP09955|CBPB1_PIG Carboxypeptidase B (Gene Name=CPB1)

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