Structure of PDB 2jev Chain A

Receptor sequence
>2jevA (length=169) Species: 9606 (Homo sapiens) [Search protein sequence]
AKFVIRPATAADCSDILRLIKELAKYEYMEEQVILTEKDLLEDGFGEHPF
YHCLVAEVPKEHWTPEGHSIVGFAMYYFTYDPWIGKLLYLEDFFVMSDYR
GFGIGSEILKNLSQVAMRCRCSSMHFLVAEWNEPSINFYKRRGASDLSSE
EGWRLFKIDKEYLLKMATE
3D structure
PDB2jev Mechanistic and Structural Analysis of Human Spermidine/Spermine N(1)-Acetyltransferase.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.57: diamine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NHQ A Y27 E32 E92 F94 F95 V96 R101 G102 G104 I105 G106 S107 L128 S136 F139 Y140 Y26 E31 E91 F93 F94 V95 R100 G101 G103 I104 G105 S106 L127 S135 F138 Y139 MOAD: Ki=6nM
BS02 NHQ A D82 W84 W154 D81 W83 W153 MOAD: Ki=6nM
Gene Ontology
Molecular Function
GO:0004145 diamine N-acetyltransferase activity
GO:0005515 protein binding
GO:0008080 N-acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0019809 spermidine binding
GO:0042802 identical protein binding
Biological Process
GO:0001525 angiogenesis
GO:0006596 polyamine biosynthetic process
GO:0009447 putrescine catabolic process
GO:0032918 spermidine acetylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:2jev, PDBe:2jev, PDBj:2jev
PDBsum2jev
PubMed17516632
UniProtP21673|SAT1_HUMAN Diamine acetyltransferase 1 (Gene Name=SAT1)

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