Structure of PDB 2jc0 Chain A

Receptor sequence
>2jc0A (length=557) [Search protein sequence]
SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSASLRQK
KVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSK
FGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEVFCVQRK
PARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRVEFLV
NTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIKS
LTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKASAACRA
AKLQDCTMLVNGDDLVVICESAGVQEDAASLRVFTEAMTRYSAPPGDPPQ
PEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPV
NSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIE
PLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRAR
SVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASQLDLSSWFVAGY
SGGDIYH
3D structure
PDB2jc0 Optimization of Novel Acyl Pyrrolidine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Leading to a Development Candidate.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 699 A R200 C366 S368 L384 G410 N411 Q446 Y448 G449 R195 C361 S363 L379 G405 N406 Q441 Y443 G444 MOAD: ic50=20uM
PDBbind-CN: -logKd/Ki=4.70,IC50=20uM
BS02 699 A L419 R422 M423 L474 H475 S476 Y477 R501 W528 K533 L414 R417 M418 L469 H470 S471 Y472 R496 W523 K528 MOAD: ic50=20uM
PDBbind-CN: -logKd/Ki=4.70,IC50=20uM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:2jc0, PDBe:2jc0, PDBj:2jc0
PDBsum2jc0
PubMed17269759
UniProtP26663|POLG_HCVBK Genome polyprotein

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