Structure of PDB 2jbo Chain A

Receptor sequence
>2jboA (length=295) Species: 9606 (Homo sapiens) [Search protein sequence]
PQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALK
MLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDG
GELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL
YTSKRPNAILKLTDFGFAKETTCYTPYYVAPEVLGPEKYDKSCDMWSLGV
IMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKML
IRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK
3D structure
PDB2jbo Structural Basis for a High Affinity Inhibitor Bound to Protein Kinase Mk2.
ChainA
Resolution3.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D186 K188 E190 N191 D207 T226
Catalytic site (residue number reindexed from 1) D143 K145 E147 N148 D164 T175
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P4O A L70 L72 K93 L141 D207 L27 L29 K50 L98 D164 PDBbind-CN: -logKd/Ki=8.07,IC50=8.5nM
BindingDB: IC50=8.5nM,EC50=49nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2jbo, PDBe:2jbo, PDBj:2jbo
PDBsum2jbo
PubMed17449059
UniProtP49137|MAPK2_HUMAN MAP kinase-activated protein kinase 2 (Gene Name=MAPKAPK2)

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