Structure of PDB 2jaj Chain A

Receptor sequence
>2jajA (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]
AFGRATHAVVRALPESLGQHALRSGEEVDVARAERQHQLYVGVLGSKLGL
QVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALE
KLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKD
YAVSTVPVADGLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYD
KLTVPDDIAANCIYLNIPNKGHVLLHRTPEEYPESAKVYEKLKDHMLIPV
SMSELEKVDGLLTCCSVLINKK
3D structure
PDB2jaj Disruption of methylarginine metabolism impairs vascular homeostasis.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.3.18: dimethylargininase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 D20 A L29 D72 F75 D78 H172 K174 V267 D268 C273 L22 D63 F66 D69 H163 K165 V258 D259 C264 MOAD: ic50<25uM
PDBbind-CN: -logKd/Ki=4.60,IC50=25uM
BindingDB: Ki=13000nM,IC50=29000nM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016403 dimethylargininase activity
GO:0016597 amino acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000052 citrulline metabolic process
GO:0003073 regulation of systemic arterial blood pressure
GO:0006525 arginine metabolic process
GO:0006527 arginine catabolic process
GO:0007263 nitric oxide mediated signal transduction
GO:0008285 negative regulation of cell population proliferation
GO:0043116 negative regulation of vascular permeability
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0046209 nitric oxide metabolic process
GO:1900038 negative regulation of cellular response to hypoxia
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2jaj, PDBe:2jaj, PDBj:2jaj
PDBsum2jaj
PubMed17273169
UniProtO94760|DDAH1_HUMAN N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (Gene Name=DDAH1)

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