Structure of PDB 2j90 Chain A

Receptor sequence
>2j90A (length=265) Species: 9606 (Homo sapiens) [Search protein sequence]
FQSMVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRR
GVSREEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDF
LAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPN
PRIKLIDFGIAHKIEGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSG
ASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRR
MTIAQSLEHSWIKAI
3D structure
PDB2j90 Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D139 K141 E143 N144 D161 T180
Catalytic site (residue number reindexed from 1) D135 K137 E139 N140 D157 T167
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IZA A L19 V27 A40 K42 L93 E94 L95 V96 I160 D161 L15 V23 A36 K38 L89 E90 L91 V92 I156 D157
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2j90, PDBe:2j90, PDBj:2j90
PDBsum2j90
PubMed18239682
UniProtO43293|DAPK3_HUMAN Death-associated protein kinase 3 (Gene Name=DAPK3)

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