Structure of PDB 2iyr Chain A

Receptor sequence
>2iyrA (length=164) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
APKAVLVGLPGSGKSTIGRRLAKALGVGLLDTDVAIEQRTGRSIADIFAT
DGEQEFRRIEEDVVRAALADHDGVLSLGGGAVTSPGVRAALAGHTVVYLE
ISAAEGVRRTGGNTAGPDRAEKYRALMAKRAPLYRRVATMRVDTNRRNPG
AVVRHILSRLQVPS
3D structure
PDB2iyr Mechanism of Phosphoryl Transfer Catalyzed by Shikimate Kinase from Mycobacterium Tuberculosis.
ChainA
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.71: shikimate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SKM A D34 I45 R58 G79 R136 D33 I44 R57 G78 R130
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004765 shikimate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
GO:0016310 phosphorylation
GO:0019632 shikimate metabolic process
GO:0019752 carboxylic acid metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2iyr, PDBe:2iyr, PDBj:2iyr
PDBsum2iyr
PubMed17020768
UniProtP9WPY3|AROK_MYCTU Shikimate kinase (Gene Name=aroK)

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