Structure of PDB 2iyf Chain A

Receptor sequence
>2iyfA (length=384) Species: 1890 (Streptomyces antibioticus) [Search protein sequence]
AHIAMFSIAAHGHVNPSLEVIRELVARGHRVTYAIPPVFADKVAATGPRP
VLYHSTLPGPDADPEAWGSTLLDNVEPFLNDAIQALPQLADAYADDIPDL
VLHDITSYPARVLARRWGVPAVSLSPNLVAWKGYEEEVAEPMWREPRQTE
RGRAYYARFEAWLKENGITEHPDTFASHPPRSLVLIPKALQPHADRVDED
VYTFVGACQEGGWQRPAGAEKVVLVSLGSAFTQPAFYRECVRAFGNLPGW
HLVLQIGTPAELGELPDNVEVHDWVPQLAILRQADLFVTHAGAGGSQEGL
ATATPMIAVPQAVDQFGNADMLQGLGVARKLATEEATADLLRETALALVD
DPEVARRLRRIQAEMAQEGGTRRAADLIEAELPA
3D structure
PDB2iyf The Crystal Structure of Two Macrolide Glycosyltransferases Provides a Blueprint for Host Cell Antibiotic Immunity.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ERY A H19 W73 N80 F84 A182 S183 D329 H13 W67 N74 F78 A176 S177 D314 PDBbind-CN: -logKd/Ki=3.75,Ki=177.3uM
BS02 UDP A S240 Q267 W289 V290 Q292 H305 G309 G310 E313 S229 Q255 W274 V275 Q277 H290 G294 G295 E298
Gene Ontology
Molecular Function
GO:0008194 UDP-glycosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0016758 hexosyltransferase activity
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:2iyf, PDBe:2iyf, PDBj:2iyf
PDBsum2iyf
PubMed17376874
UniProtQ53685|OLED_STRAT Oleandomycin glycosyltransferase (Gene Name=oleD)

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