Structure of PDB 2ixl Chain A

Receptor sequence
>2ixlA (length=196) Species: 1307 (Streptococcus suis) [Search protein sequence]
TENFFGKTLAARPVEAIPGMLEFDIPVHGDNRGWFKENFQKEKMLPLGFP
ESFFAEGKLQNNVSFSRKNVLRGLHAEPWDKYISVADGGKVLGTWVDLRE
GETFGNTYQTVIDASKSIFVPRGVANGFQVLSDFVAYSYLVNDYWALELK
PKYAFVNYADPSLDIKWENLEEAEVSEADENHPFLKDVKPLRKEDL
3D structure
PDB2ixl Rmlc, a C3' and C5' Carbohydrate Epimerase, Appears to Operate Via an Intermediate with an Unusual Twist Boat Conformation.
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H76 K82 Y140 D180
Catalytic site (residue number reindexed from 1) H75 K81 Y139 D179
Enzyme Commision number 5.1.3.13: dTDP-4-dehydrorhamnose 3,5-epimerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TRH A R73 H76 E78 K82 N127 W146 R72 H75 E77 K81 N126 W145
BS02 TRH A R33 F36 E38 R32 F35 E37
Gene Ontology
Molecular Function
GO:0008830 dTDP-4-dehydrorhamnose 3,5-epimerase activity
GO:0016853 isomerase activity
Biological Process
GO:0019305 dTDP-rhamnose biosynthetic process
GO:0045226 extracellular polysaccharide biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ixl, PDBe:2ixl, PDBj:2ixl
PDBsum2ixl
PubMed17046787
UniProtQ8GIQ0

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