Structure of PDB 2ixh Chain A

Receptor sequence
>2ixhA (length=184) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
SMAMKATRLAIPDVILFEPRVFGDDRGFFFESYNQRAFEEACGHPVSFVQ
DNHSRSARGVLRGLHYQIRQAQGKLVRATLGEVFDVAVDLRRGSPTFGQW
VGERLSAENKRQMWIPAGFAHGFVVLSEYAEFLYKTTDFWAPEHERCIVW
NDPELKIDWPLQDAPLLSEKDRQGKAFADADCFP
3D structure
PDB2ixh RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H65 K74 Y134 D171
Catalytic site (residue number reindexed from 1) H65 K74 Y134 D171
Enzyme Commision number 5.1.3.13: dTDP-4-dehydrorhamnose 3,5-epimerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TRH A R62 H65 K74 H121 Y134 W140 K170 R62 H65 K74 H121 Y134 W140 K170 MOAD: Ka=11600M^-1
Gene Ontology
Molecular Function
GO:0008830 dTDP-4-dehydrorhamnose 3,5-epimerase activity
GO:0016853 isomerase activity
Biological Process
GO:0009103 lipopolysaccharide biosynthetic process
GO:0009244 lipopolysaccharide core region biosynthetic process
GO:0019305 dTDP-rhamnose biosynthetic process
GO:0045226 extracellular polysaccharide biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ixh, PDBe:2ixh, PDBj:2ixh
PDBsum2ixh
PubMed17046787
UniProtQ9HU21|RMLC_PSEAE dTDP-4-dehydrorhamnose 3,5-epimerase (Gene Name=rmlC)

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