Structure of PDB 2ix0 Chain A

Receptor sequence
>2ix0A (length=637) Species: 562 (Escherichia coli) [Search protein sequence]
DDPLLAQLKQQLHSQTPRAEGVVKATEFGFLEVDAQKSYFIPPPQMKKVM
HGDRIIAVIHSERESAEPEELVEPFLTRFVGKVQGKNDRLAIVPDHPLLK
DAIPCRAARGLNHEFKEGDWAVAEMRRHPLKGDRSFYAELTQYITFGDDH
FVPWWVTLARHNLEKEAPDGVATEMLDEGLVREDLTALDFVTIDSASTED
MDDALFAKALPDDKLQLIVAIADPTAWIAEGSKLDKAAKIRAFTNYLPGF
NIPMLPRELSDDLCSLRANEVRPVLACRMTLSADGTIEDNIEFFAATIES
KAKLVYDQVSDWLENTGDWQPESEAIAEQVRLLAQICQRRGEWRHNHALV
FKDRPDYRFILGEKGEVLDIVAEPRRIANRIVEEAMIAANICAARVLRDK
LGFGIYNVHMGFDPANADALAALLKTHGLHVDAEEVLTLDGFCKLRRELD
AQPTGFLDSRIRRFQSFAEISTEPGPHFGLGLEAYATWTSPIRKYGDMIN
HRLLKAVIKGETATRPQDEITVQMAERRRLNRMAERDVGDWLYARFLKDK
AGTDTRFAAEIVDISRGGMRVRLVDNGAIAFIPAPFLHAVRDELVCSQEN
GTVQIKGETVYKVTDVIDVTIAEVRMETRSIIARPVA
3D structure
PDB2ix0 Unravelling the Dynamics of RNA Degradation by Ribonuclease II and its RNA-Bound Complex
ChainA
Resolution2.44 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D201 D207 D209 D210 Y313 R500
Catalytic site (residue number reindexed from 1) D194 D200 D202 D203 Y306 R493
Enzyme Commision number 3.1.13.1: exoribonuclease II.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C5P A F82 F86 D102 H103 R167 F75 F79 D95 H96 R160
BS02 MG A D201 D210 D194 D203
BS03 CA A P101 D102 H103 L106 P94 D95 H96 L99
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004527 exonuclease activity
GO:0004540 RNA nuclease activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0008859 exoribonuclease II activity
Biological Process
GO:0006401 RNA catabolic process
GO:0006402 mRNA catabolic process
GO:0016070 RNA metabolic process
GO:0016078 tRNA decay
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ix0, PDBe:2ix0, PDBj:2ix0
PDBsum2ix0
PubMed16957732
UniProtP30850|RNB_ECOLI Exoribonuclease 2 (Gene Name=rnb)

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