Structure of PDB 2iwd Chain A

Receptor sequence
>2iwdA (length=246) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
DKYETNVSYKKLNQLAPYFKGFDGSFVLYNEREQAYSIYNEPESKQRYSP
NSTYKIYLALMAFDQNLLSLNHTEQQWDKHQYPFKEWNQDQNLNSSMKYS
VNWYYENLNKHLRQDEVKSYLDLIEYGNEEISGNENYWNESSLKISAIEQ
VNLLKNMKQHNMHFDNKAIEKVENSMTLKQKDTYKYVGKTGTGIVNHKEA
NGWFVGYVETKDNTYYFATHLKGEDNANGEKAQQISERILKEMELI
3D structure
PDB2iwd Unbound and Acylated Structures of the Mecr1 Extracellular Antibiotic-Sensor Domain Provide Insights Into the Signal-Transduction System that Triggers Methicillin Resistance.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S391 K394 S439 Y444 W477 T531
Catalytic site (residue number reindexed from 1) S52 K55 S100 Y105 W138 T192
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1S6 A N390 S391 F423 S439 N441 N478 T529 T531 G532 I533 N51 S52 F84 S100 N102 N139 T190 T192 G193 I194
Gene Ontology
Molecular Function
GO:0008658 penicillin binding

View graph for
Molecular Function
External links
PDB RCSB:2iwd, PDBe:2iwd, PDBj:2iwd
PDBsum2iwd
PubMed16846613
UniProtP0A0B0|MECR_STAAN Methicillin resistance mecR1 protein (Gene Name=mecR1)

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