Structure of PDB 2iwb Chain A

Receptor sequence
>2iwbA (length=246) Species: 158879 (Staphylococcus aureus subsp. aureus N315) [Search protein sequence]
DKYETNVSYKKLNQLAPYFKGFDGSFVLYNEREQAYSIYNEPESKQRYSP
NSTYKIYLALMAFDQNLLSLNHTEQQWDKHQYPFKEWNQDQNLNSSMKYS
VNWYYENLNKHLRQDEVKSYLDLIEYGNEEISGNENYWNESSLKISAIEQ
VNLLKNMKQHNMHFDNKAIEKVENSMTLKQKDTYKYVGKTGTGIVNHKEA
NGWFVGYVETKDNTYYFATHLKGEDNANGEKAQQISERILKEMELI
3D structure
PDB2iwb Unbound and Acylated Structures of the Mecr1 Extracellular Antibiotic-Sensor Domain Provide Insights Into the Signal-Transduction System that Triggers Methicillin Resistance.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) S391 K394 S439 Y444 W477 T531
Catalytic site (residue number reindexed from 1) S52 K55 S100 Y105 W138 T192
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L406 H411 Q414 N446 H450 L67 H72 Q75 N107 H111
Gene Ontology
Molecular Function
GO:0008658 penicillin binding

View graph for
Molecular Function
External links
PDB RCSB:2iwb, PDBe:2iwb, PDBj:2iwb
PDBsum2iwb
PubMed16846613
UniProtP0A0B0|MECR_STAAN Methicillin resistance mecR1 protein (Gene Name=mecR1)

[Back to BioLiP]