Structure of PDB 2ivv Chain A

Receptor sequence
>2ivvA (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
GPLSLSVDAFKIKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYT
TVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLI
VEYAKYGSLRGFLRESRLTMGDLISFAWQISQGMQYLAEMSLVHRDLAAR
NILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIY
TTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSE
EMYRLMLQCWKQEPDKRPVFADISKDLEKMMVK
3D structure
PDB2ivv Structure and chemical inhibition of the RET tyrosine kinase domain.
ChainA
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D874 A876 R878 N879 D892
Catalytic site (residue number reindexed from 1) D146 A148 R150 N151 D164
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PP1 A L730 V738 A756 K758 V804 A807 L881 S891 D892 L27 V35 A53 K55 V101 A104 L153 S163 D164 BindingDB: IC50=11nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2ivv, PDBe:2ivv, PDBj:2ivv
PDBsum2ivv
PubMed16928683
UniProtP07949|RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (Gene Name=RET)

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