Structure of PDB 2iux Chain A

Receptor sequence

>2iuxA (length=577) Species: 9606 (Homo sapiens)

DEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIA
NHTLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKIL
LDMETTYSVATVCHPNGSCLQLEPDLTNVMATSRKYEDLLWAWEGWRDKA
GRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLERLFQE
LQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDL
VVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWQKS
MLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQ
YFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSGGSD
EHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRL
KYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQA
AGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPQMSAS
AMLSYFKPLLDWLRTENELHGEKLGWP

3D structure

• PDB: 2iux Structure of Testis Ace Glycosylation Mutants and Evidence for Conserved Domain Movement.
• Chain: A
• Resolution: 2.8 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H353 A354 H383 E384 H387 E411 H513 Y523
• Catalytic site (residue number reindexed from 1): H314 A315 H344 E345 H348 E372 H473 Y483
• Enzyme Commision number: 3.4.15.1: peptidyl-dipeptidase A.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	H383 H387 E411	H344 H348 E372
BS02	CL	A	R186 W486 R489	R147 W446 R449
BS03	CL	A	Y224 P407 R522	Y185 P368 R482
BS04	NXA	A	H353 H513 Y523	H314 H473 Y483

Gene Ontology

Molecular Function

• GO:0008237 metallopeptidase activity
• GO:0008241 peptidyl-dipeptidase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:2iux, PDBe:2iux, PDBj:2iux
• PDBsum: 2iux
• PubMed: 17042482
• UniProt: P12821|ACE_HUMAN Angiotensin-converting enzyme (Gene Name=ACE)