Structure of PDB 2it0 Chain A

Receptor sequence
>2it0A (length=145) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
ELVDTTEMYLRTIYDLEEEGVTPLRARIAERLDQSGPTVSQTVSRMERDG
LLRVAGDRHLELTEKGRALAIAVMRKHRLAERLLVDVIGLPWEEVHAEAC
RWEHVMSEDVERRLVKVLNNPTTSPFGNPIPGLVELGVASENLYF
3D structure
PDB2it0 Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R27 A28 R29 R60 R25 A26 R27 R58 PDBbind-CN: Kd=25uM
BS02 dna A T7 Q36 S37 P39 T40 R47 R50 T5 Q34 S35 P37 T38 R45 R48 PDBbind-CN: Kd=25uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0046914 transition metal ion binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:2it0, PDBe:2it0, PDBj:2it0
PDBsum2it0
PubMed17209554
UniProtP9WMH1|IDER_MYCTU Iron-dependent repressor IdeR (Gene Name=ideR)

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