Structure of PDB 2isw Chain A

Receptor sequence
>2iswA (length=307) Species: 5741 (Giardia intestinalis) [Search protein sequence]
PLCTLRQMLGEARKHKYGVGAFNVNNMEQIQGIMKAVVQLKSPVILQCSR
GALKYSDMIYLKKLCEAALEKHPDIPICIHLDHGDTLESVKMAIDLGFSS
VMIDASHHPFDENVRITKEVVAYAHARSVSVEAELGTLVQLTEPQDAKKF
VELTGVDALAVAIGTSHGAYKFKSRLAIDRVKTISDLTGIPLVMHGSSSV
PKDVKDMINKYGGKMPDAVGVPIESIVHAIGEGVCKINVDSDSRMAMTGA
IRKVFVEHPEKFDPRDYLGPGRDAITEMLIPKIKAFGSAGHAGDYKVVSL
EEAKAWY
3D structure
PDB2isw Characterization, kinetics, and crystal structures of fructose-1,6-bisphosphate aldolase from the human parasite, Giardia lamblia.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.2.13: fructose-bisphosphate aldolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H84 H178 H210 H83 H167 H195
BS02 PGH A D83 H178 G179 K182 H210 G211 S213 N253 D255 S256 D82 H167 G168 K171 H195 G196 S198 N238 D240 S241 MOAD: Ki=37nM
PDBbind-CN: -logKd/Ki=7.43,Ki=37nM
Gene Ontology
Molecular Function
GO:0004332 fructose-bisphosphate aldolase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016829 lyase activity
GO:0016832 aldehyde-lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006096 glycolytic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2isw, PDBe:2isw, PDBj:2isw
PDBsum2isw
PubMed17166851
UniProtA8B2U2|ALF_GIAIC Fructose-bisphosphate aldolase (Gene Name=fba)

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