Structure of PDB 2irx Chain A

Receptor sequence
>2irxA (length=283) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
QRVTLTNADKVLYPATGTTKSDIFDYYAGVAEVMLGHIAGRPATRKRWPN
GVDQPAFFEKQLALSAPPWLSRATVAHRSGTTTYPIIDSATGLAWIAQQA
ALEVHVPQWRFVAEPGSGELNPGPATRLVFDLDPGEGVMMAQLAEVARAV
RDLLADIGLVTFPVTSGSKGLHLYTPLDEPVSSRGATVLAKRVAQRLEQA
MPALVTSTMTKSLRAGKVFVDWSQNSGSKTTIAPYSLRGRTHPTVAAPRT
WAELDDPALRQLSYDEVLTRIARDGDLLERLDA
3D structure
PDB2irx Structure and function of a mycobacterial NHEJ DNA repair polymerase.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D140 D142 D131 D133
BS02 GTP A K55 F67 H114 D140 S175 S177 K178 H181 Q233 T239 R247 K46 F58 H105 D131 S166 S168 K169 H172 Q224 T230 R238
External links
PDB RCSB:2irx, PDBe:2irx, PDBj:2irx
PDBsum2irx
PubMed17174332
UniProtP9WNV3|LIGD_MYCTU Multifunctional non-homologous end joining DNA repair protein LigD (Gene Name=ligD)

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