Structure of PDB 2ioc Chain A

Receptor sequence
>2iocA (length=218) Species: 10090 (Mus musculus) [Search protein sequence]
TLPHGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENQGHPPPVP
RPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLAILL
RAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDSIAA
LKALEQASKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWKPQALL
QWVDEHARPFSTVKPMYG
3D structure
PDB2ioc The Crystal Structure of TREX1 Explains the 3' Nucleotide Specificity and Reveals a Polyproline II Helix for Protein Partnering.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D18 E20 D200 D14 E16 D184
BS02 D5M A D18 E20 A21 G23 L24 A81 I84 Y129 D14 E16 A17 G19 L20 A73 I76 Y121
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:2ioc, PDBe:2ioc, PDBj:2ioc
PDBsum2ioc
PubMed17293595
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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