Structure of PDB 2imk Chain A

Receptor sequence
>2imkA (length=220) Species: 7165 (Anopheles gambiae) [Search protein sequence]
SNLVLYTLHLSPPCRAVELTAKALGLELEQKTINLLTGDHLKPEFVKLNP
QHTIPVLDDNGTIITESHAIMIYLVTKYGKDDSLYPKDPVKQARVNSALH
FESGVLFARMRFIFERILFFGKSDIPEDRVEYVQKSYELLEDTLVDDFVA
GPTMTIADFSCISTISSIMGVVPLEQSKHPRIYAWIDRLKQLPYYEEANG
GGGTDLGKFVLAKKEENAKA
3D structure
PDB2imk Structure of an insect epsilon class glutathione S-transferase from the malaria vector Anopheles gambiae provides an explanation for the high DDT-detoxifying activity
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S12
Catalytic site (residue number reindexed from 1) S11
Enzyme Commision number 2.5.1.18: glutathione transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTX A S12 P14 L36 H41 H53 T54 I55 E67 S68 F108 R112 L207 S11 P13 L35 H40 H52 T53 I54 E66 S67 F107 R111 L206
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004364 glutathione transferase activity
Biological Process
GO:0006749 glutathione metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2imk, PDBe:2imk, PDBj:2imk
PDBsum2imk
PubMed18778777
UniProtQ7PVS6

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