Structure of PDB 2imd Chain A

Receptor sequence
>2imdA (length=203) Species: 303 (Pseudomonas putida) [Search protein sequence]
MIVDFYFDFLSPFSYLANQRLSKLAQDYGLTIRYNAIDLARVKIAIGNVG
PSNRDLKVKLDYLKVDLQRWAQLYGIPLVFPANYNSRRMNIGFYYSGAEA
QAAAYVNVVFNAVWGEGIAPDLESLPALVSEKLGWDRSAFEHFLSSNAAT
ERYDEQTHAAIERKVFGVPTMFLGDEMWWGNDRLFMLESAMGRLCRQNAD
LSS
3D structure
PDB2imd 2-Hydroxychromene-2-carboxylic Acid Isomerase: A Kappa Class Glutathione Transferase from Pseudomonas putida
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.99.1.4: 2-hydroxychromene-2-carboxylate isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GSH A S11 F13 G167 V168 W179 G180 N181 D182 S11 F13 G167 V168 W179 G180 N181 D182 MOAD: Kd=14uM
PDBbind-CN: -logKd/Ki=8.30,Kd=5nM
BS02 TOH A P12 F13 S52 R54 Y84 P12 F13 S52 R54 Y84 MOAD: Ki=136uM
BS03 2C2 A P12 F13 S52 N53 R54 P12 F13 S52 N53 R54 MOAD: Kd=19uM
Gene Ontology
Molecular Function
GO:0004364 glutathione transferase activity
GO:0004602 glutathione peroxidase activity
GO:0016491 oxidoreductase activity
GO:0016853 isomerase activity
GO:0018845 2-hydroxychromene-2-carboxylate isomerase activity
Biological Process
GO:0006749 glutathione metabolic process
GO:0009056 catabolic process
GO:0098869 cellular oxidant detoxification
GO:1901170 naphthalene catabolic process
Cellular Component
GO:0005777 peroxisome

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Biological Process
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Cellular Component
External links
PDB RCSB:2imd, PDBe:2imd, PDBj:2imd
PDBsum2imd
PubMed17508726
UniProtQ51948|NAHD_PSEPU 2-hydroxychromene-2-carboxylate isomerase (Gene Name=nahD)

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