Structure of PDB 2ihq Chain A

Receptor sequence
>2ihqA (length=248) Species: 10116 (Rattus norvegicus) [Search protein sequence]
PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVF
NEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDG
LKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIA
RELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT
3D structure
PDB2ihq Discovery of potent, orally-active, and muscle-selective androgen receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 LG7 A L704 N705 L707 G708 Q711 M742 M745 V746 M749 F764 M780 M787 L873 F876 T877 M895 L34 N35 L37 G38 Q41 M72 M75 V76 M79 F94 M110 M117 L203 F206 T207 M225 MOAD: Ki=3.2nM
PDBbind-CN: -logKd/Ki=8.49,Ki=3.2nM
External links
PDB RCSB:2ihq, PDBe:2ihq, PDBj:2ihq
PDBsum2ihq
PubMed17181141
UniProtP15207|ANDR_RAT Androgen receptor (Gene Name=Ar)

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