Structure of PDB 2if8 Chain A

Receptor sequence
>2if8A (length=255) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
GLLIFKPAFPQELEFYKAIQGDAPLCSWMPTYLGVLNESKQYLVLENLLY
GFSKPNILDIKLGKTLYDSKASLEKRERMKRVSETTTSGSLGFRICGMKI
QKNPSVLNQLSLEYYEEEADSDYIFINKLYGRSRTDQNVSDAIELYFNNP
HLSDARKHQLKKTFLKRLQLFYNTMLEEEVRMISSSLLFIYEGDPERWEL
LNDVDKLMRDDFIDSLSSMSLIDFAHSEITPGKGYDENVIEGVETLLDIF
MKFLE
3D structure
PDB2if8 Crystal structure of inositol phosphate multikinase 2 and implications for substrate specificity.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.127: inositol-trisphosphate 3-kinase.
2.7.1.151: inositol-polyphosphate multikinase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 MN A K133 D325 K61 D223
BS02 CA A E271 N274 E199 N202
BS03 ADP A K31 P67 E118 N119 L120 D131 D325 K6 P30 E46 N47 L48 D59 D223
Gene Ontology
Molecular Function
GO:0000823 inositol-1,4,5-trisphosphate 6-kinase activity
GO:0000824 inositol-1,4,5,6-tetrakisphosphate 3-kinase activity
GO:0000825 inositol-1,3,4,5-tetrakisphosphate 6-kinase activity
GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity
GO:0005524 ATP binding
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0030674 protein-macromolecule adaptor activity
GO:0046872 metal ion binding
GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0047326 inositol-1,3,4,6-tetrakisphosphate 5-kinase activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000821 regulation of arginine metabolic process
GO:0006525 arginine metabolic process
GO:0016236 macroautophagy
GO:0016310 phosphorylation
GO:0032958 inositol phosphate biosynthetic process
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0050821 protein stabilization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0090575 RNA polymerase II transcription regulator complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:2if8, PDBe:2if8, PDBj:2if8
PDBsum2if8
PubMed17050532
UniProtP07250|IPMK_YEAST Inositol polyphosphate multikinase (Gene Name=ARG82)

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