Structure of PDB 2iew Chain A

Receptor sequence
>2iewA (length=258) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
GLLIFKPAFPQELEFYKAIQGDAPLCSWMPTYLGVLNESKQYLVLENLLY
GFSKPNILDIKLGKTLYDSKASLEKRERMKRVSETTTSGSLGFRICGMKI
QKNPSVLNQLSLEYYEEEADSDYIFINKLYGRSRTDQNVSDAIELYFNNP
HLSDARKHQLKKTFLKRLQLFYNTMLEEEVRMISSSLLFIYEGDPERWEL
LNDVDKLMRDDFIDSLSSMSLIDFAHSEITPGKGYDENVIEGVETLLDIF
MKFLEHHH
3D structure
PDB2iew Crystal structure of inositol phosphate multikinase 2 and implications for substrate specificity.
ChainA
Resolution2.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.1.127: inositol-trisphosphate 3-kinase.
2.7.1.151: inositol-polyphosphate multikinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E271 N274 E199 N202
Gene Ontology
Molecular Function
GO:0000823 inositol-1,4,5-trisphosphate 6-kinase activity
GO:0000824 inositol-1,4,5,6-tetrakisphosphate 3-kinase activity
GO:0000825 inositol-1,3,4,5-tetrakisphosphate 6-kinase activity
GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity
GO:0005524 ATP binding
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0030674 protein-macromolecule adaptor activity
GO:0046872 metal ion binding
GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0047326 inositol-1,3,4,6-tetrakisphosphate 5-kinase activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000821 regulation of arginine metabolic process
GO:0006525 arginine metabolic process
GO:0016236 macroautophagy
GO:0016310 phosphorylation
GO:0032958 inositol phosphate biosynthetic process
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0050821 protein stabilization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0090575 RNA polymerase II transcription regulator complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2iew, PDBe:2iew, PDBj:2iew
PDBsum2iew
PubMed17050532
UniProtP07250|IPMK_YEAST Inositol polyphosphate multikinase (Gene Name=ARG82)

[Back to BioLiP]