Structure of PDB 2ie7 Chain A

Receptor sequence

>2ie7A (length=318) Species: 10116 (Rattus norvegicus) [Search protein sequence]

ALRGTVTDFSGFDGRADAEVLRKAMKGLGTDEDSILNLLTARSNAQRQQI
AEEFKTLFGRDLVNDMKSELTGKFEKLIVALMKPSRLYDAYELKHALKGA
GTDEKVLTEIIASRTPEELRAIKQAYEEEYGSNLEDDVVGDTSGYYQRML
VVLLQANRDPDTAIDDAQVELDAQALFQAGELKWGTDEEKFITILGTRSV
SHLRRVFDKYMTISGFQIEETIDRETSGNLENLLLAVVKSIRSIPAYLAE
TLYYAMKGAGTDDHTLIRVIVSRSEIDLFNIRKEFRKNFATSLYSMIKGD
TSGDYKKALLLLCGGEDD

3D structure

PDB

2ie7 Protein Crystallography under Xenon and Nitrous Oxide Pressure: Comparison with In Vivo Pharmacology Studies and Implications for the Mechanism of Inhaled Anesthetic Action

Chain

Resolution

1.75 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	A	G181 K184 G186 E226	G180 K183 G185 E225
BS02	CA	A	M26 G28 G30 E70	M25 G27 G29 E69
BS03	CA	A	D224 T227 S228 E232	D223 T226 S227 E231
BS04	CA	A	M257 G259 G261 D301	M256 G258 G260 D300
BS05	CA	A	K68 L71 E76	K67 L70 E75
BS06	CA	A	T31 E33	T30 E32
BS07	CA	A	G186 T187	G185 T186
BS08	N2O	A	T187 F192 T227 L235	T186 F191 T226 L234
BS09	N2O	A	M67 I79 V80	M66 I78 V79

Gene Ontology

	Molecular Function
GO:0001786	phosphatidylserine binding
GO:0005388	P-type calcium transporter activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0005544	calcium-dependent phospholipid binding
GO:0017046	peptide hormone binding
GO:0030971	receptor tyrosine kinase binding
GO:0042802	identical protein binding

	Biological Process
GO:0007596	blood coagulation
GO:0030195	negative regulation of blood coagulation
GO:0043065	positive regulation of apoptotic process
GO:0050819	negative regulation of coagulation
GO:0051592	response to calcium ion
GO:0070588	calcium ion transmembrane transport
GO:0071284	cellular response to lead ion
GO:0097066	response to thyroid hormone
GO:0097211	cellular response to gonadotropin-releasing hormone
GO:1901317	regulation of flagellated sperm motility
GO:1902721	negative regulation of prolactin secretion

	Cellular Component
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0008021	synaptic vesicle
GO:0009897	external side of plasma membrane
GO:0012506	vesicle membrane
GO:0014704	intercalated disc
GO:0030018	Z disc
GO:0030425	dendrite
GO:0030672	synaptic vesicle membrane
GO:0042383	sarcolemma
GO:0042995	cell projection
GO:0043025	neuronal cell body
GO:0043204	perikaryon
GO:0043679	axon terminus
GO:0072563	endothelial microparticle

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:2ie7, PDBe:2ie7, PDBj:2ie7
PDBsum	2ie7
PubMed	17028130
UniProt	P14668\|ANXA5_RAT Annexin A5 (Gene Name=Anxa5)

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