Structure of PDB 2ic1 Chain A

Receptor sequence

>2ic1A (length=185) Species: 9606 (Homo sapiens)

VLKPRTLADLIRILHQLFAGDEVNVEEVQAIMEAYESDPTEWAMYAKFDQ
YRYTRNLVDQGNGKFNLMILCWGEGHGSSIHDHTNSHCFLKMLQGNLKET
LFAWPDKKSNEMVKKSERVLRENQCAYINDSIGLHRVENISHTEPAVSLH
LYSPPFDTCHAFDQRTGHKNKVTMTFHSKFGIRTP

3D structure

• PDB: 2ic1 An Insight into the Mechanism of Human Cysteine Dioxygenase: KEY ROLES OF THE THIOETHER-BONDED TYROSINE-CYSTEINE COFACTOR.
• Chain: A
• Resolution: 2.7 Å

Enzymatic activity

• Enzyme Commision number: 1.13.11.20: cysteine dioxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FE2	A	H86 H88 H140	H81 H83 H135
BS02	CYS	A	R60 H86 H88 H140 H155 Y157	R55 H81 H83 H135 H150 Y152
BS03	CYS	A	Q34 R123 Q129 C130 A131 Y132	Q29 R118 Q124 C125 A126 Y127

Gene Ontology

Molecular Function

• GO:0005506 iron ion binding
• GO:0008198 ferrous iron binding
• GO:0008270 zinc ion binding
• GO:0016151 nickel cation binding
• GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
• GO:0017172 cysteine dioxygenase activity
• GO:0046872 metal ion binding
• GO:0051213 dioxygenase activity

Biological Process

• GO:0000097 sulfur amino acid biosynthetic process
• GO:0006534 cysteine metabolic process
• GO:0006954 inflammatory response
• GO:0007595 lactation
• GO:0019448 L-cysteine catabolic process
• GO:0033762 response to glucagon
• GO:0042412 taurine biosynthetic process
• GO:0043200 response to amino acid
• GO:0045471 response to ethanol
• GO:0051384 response to glucocorticoid
• GO:0051591 response to cAMP

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:2ic1, PDBe:2ic1, PDBj:2ic1
• PDBsum: 2ic1
• PubMed: 17135237
• UniProt: Q16878|CDO1_HUMAN Cysteine dioxygenase type 1 (Gene Name=CDO1)