Structure of PDB 2iag Chain A

Receptor sequence
>2iagA (length=471) Species: 9606 (Homo sapiens) [Search protein sequence]
RTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGR
YVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKA
RMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFL
LRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSL
SVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEM
QARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQTTL
PQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRG
DRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNY
NMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSR
YGFGLMQPEHDVPVRYRIRPH
3D structure
PDB2iag Crystal Structure of the Human Prostacyclin Synthase
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.1.152: hydroperoxy icosatetraenoate dehydratase.
5.3.99.4: prostaglandin-I synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A M124 Q280 A283 T284 N287 M288 P355 P433 W434 C441 L442 G443 Y446 A447 M102 Q258 A261 T262 N265 M266 P325 P403 W404 C411 L412 G413 Y416 A417
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008116 prostaglandin-I synthase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016829 lyase activity
GO:0016853 isomerase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0106256 hydroperoxy icosatetraenoate dehydratase activity
Biological Process
GO:0001516 prostaglandin biosynthetic process
GO:0006629 lipid metabolic process
GO:0006690 icosanoid metabolic process
GO:0019371 cyclooxygenase pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway
GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0050728 negative regulation of inflammatory response
GO:0071347 cellular response to interleukin-1
GO:0071354 cellular response to interleukin-6
GO:0071456 cellular response to hypoxia
GO:0097190 apoptotic signaling pathway
GO:1900119 positive regulation of execution phase of apoptosis
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005901 caveola
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2iag, PDBe:2iag, PDBj:2iag
PDBsum2iag
PubMed17020766
UniProtQ16647|PTGIS_HUMAN Prostacyclin synthase (Gene Name=PTGIS)

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