Structure of PDB 2i62 Chain A

Receptor sequence
>2i62A (length=257) Species: 10090 (Mus musculus) [Search protein sequence]
FTSKDTYLSHFNPRDYLEKYYSFGSRHCAENEILRHLLKNLFKIFCLGAV
KGELLIDIGSGPTIYQLLSACESFTEIIVSDYTDQNLWELQKWLKKEPGA
FDWSPVVTYVCDLEGNRMKGPEKEEKLRRAIKQVLKCDVTQSQPLGGVSL
PPADCLLSTLCLDAACPDLPAYRTALRNLGSLLKPGGFLVMVDALKSSYY
MIGEQKFSSLPLGWETVRDAVEEAGYTIEQFEVISQNYSSTTSNNEGLFS
LVGRKPG
3D structure
PDB2i62 The Crystal Structure of Mouse Nicotinamide N-methyltransferase in complex with SAH
ChainA
Resolution1.8 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.1: nicotinamide N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A Y12 Y21 Y26 G64 S65 T68 Y70 D86 Y87 D143 V144 T164 L165 A170 Y7 Y16 Y21 G59 S60 T63 Y65 D81 Y82 D138 V139 T159 L160 A165
Gene Ontology
Molecular Function
GO:0008112 nicotinamide N-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0006769 nicotinamide metabolic process
GO:0009410 response to xenobiotic stimulus
GO:0031100 animal organ regeneration
GO:0032259 methylation
GO:0045722 positive regulation of gluconeogenesis
GO:0090312 positive regulation of protein deacetylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2i62, PDBe:2i62, PDBj:2i62
PDBsum2i62
PubMed
UniProtO55239|NNMT_MOUSE Nicotinamide N-methyltransferase (Gene Name=Nnmt)

[Back to BioLiP]