Structure of PDB 2i5f Chain A

Receptor sequence
>2i5fA (length=99) Species: 9606 (Homo sapiens) [Search protein sequence]
FTGVIIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAI
HLRGCVVTSVESEENLFEIITADEVHYFLQAATPKERTEWIKAIQMASR
3D structure
PDB2i5f Structural analysis of the carboxy terminal PH domain of pleckstrin bound to D-myo-inositol 1,2,3,5,6-pentakisphosphate.
ChainA
Resolution1.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5IP A K253 G255 H256 R257 R258 R264 Y277 K13 G15 H16 R17 R18 R24 Y37 MOAD: ic50=2.2uM
PDBbind-CN: -logKd/Ki=5.12,IC50=7.5uM
External links
PDB RCSB:2i5f, PDBe:2i5f, PDBj:2i5f
PDBsum2i5f
PubMed18034889
UniProtP08567|PLEK_HUMAN Pleckstrin (Gene Name=PLEK)

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