Structure of PDB 2i4i Chain A

Receptor sequence
>2i4iA (length=408) Species: 9606 (Homo sapiens) [Search protein sequence]
MVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKE
KRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQY
PISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERG
CHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVE
QDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGTSENITQKVV
WVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTS
IHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPS
DIEEYVHRIGRTGRNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLE
NMAYEHHY
3D structure
PDB2i4i Crystal Structure of Conserved Domains 1 and 2 of the Human DEAD-box Helicase DDX3X in Complex with the Mononucleotide AMP
ChainA
Resolution2.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A Y200 T204 Q207 T226 G227 G229 K230 T231 Y34 T38 Q41 T60 G61 G63 K64 T65
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:2i4i, PDBe:2i4i, PDBj:2i4i
PDBsum2i4i
PubMed17631897
UniProtO00571|DDX3X_HUMAN ATP-dependent RNA helicase DDX3X (Gene Name=DDX3X)

[Back to BioLiP]