Structure of PDB 2i4g Chain A

Receptor sequence
>2i4gA (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
KTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPEN
RGKNRYNNILPYDATRVKLSNVCSDYINASYIPGNNFRREYIVTQGPLPG
TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQ
MLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLI
QFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVD
IYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLR
3D structure
PDB2i4g Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
ChainA
Resolution1.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1870 C1904 R1910 T1911 Q1948
Catalytic site (residue number reindexed from 1) D189 C223 R229 T230 Q267
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UA1 A Y1733 I1736 D1870 H1871 C1904 S1905 A1906 V1908 G1909 R1910 H1945 Q1948 Y56 I59 D189 H190 C223 S224 A225 V227 G228 R229 H264 Q267
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2i4g, PDBe:2i4g, PDBj:2i4g
PDBsum2i4g
PubMed17139078
UniProtP23467|PTPRB_HUMAN Receptor-type tyrosine-protein phosphatase beta (Gene Name=PTPRB)

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