Structure of PDB 2i2c Chain A

Receptor sequence
>2i2cA (length=264) Species: 169963 (Listeria monocytogenes EGD-e) [Search protein sequence]
MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLS
AFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSY
PLLKTTVKYGIGKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGD
GLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLV
FPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRS
FPFWRRVHDSFIED
3D structure
PDB2i2c NAD kinases use substrate-assisted catalysis for specific recognition of NAD.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.23: NAD(+) kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DTA A D45 F74 Y75 N122 E123 T161 A162 Y163 S166 D45 F74 Y75 N122 E123 T161 A162 Y163 S166 MOAD: Ki=0.02mM
PDBbind-CN: -logKd/Ki=4.70,Ki=0.02mM
Gene Ontology
Molecular Function
GO:0003951 NAD+ kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006741 NADP biosynthetic process
GO:0016310 phosphorylation
GO:0019674 NAD metabolic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:2i2c, PDBe:2i2c, PDBj:2i2c
PDBsum2i2c
PubMed17686780
UniProtQ8Y8D7|NADK1_LISMO NAD kinase 1 (Gene Name=nadK1)

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