Structure of PDB 2i14 Chain A

Receptor sequence
>2i14A (length=389) Species: 2261 (Pyrococcus furiosus) [Search protein sequence]
MKRFYIANEDEIKAGKTTDVYFLRTKKILEVKNIRKKVLADVTTTSLPNN
WRWGVLVGVEEVAKLLEGIPVNVYAMPEGTIFHPYEPVLQIEGDYADFGI
YETALLGMLSQASGIATAALRIKIAAKFKPVYSFGIRHMHPAIAPMIDRA
AFIGGCDGVSGVLGAEMMGEKAVGTMPHALIITVGDQVKAWKYFDEVIEE
EVPRIALVDTFYDEKVEAVMAAEALGKKLFAVRLDTPSSRRGNFRKIIEE
VRWELKVRGYDWVKIFVSGGLDEEKIKEIVDVVDAFGVGGAIASAKPVDF
ALDIVEVEGKPIAKRGKLSGRKQVYRCENGHYHVVPANKKLERCPVCNAK
VEPLLKPIIENGEIVVEFPKAREIREYVLEQAKKFNLEI
3D structure
PDB2i14 Crystal structure of nicotinate-nucleotide pyrophosphorylase from Pyrococcus furiosus
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.4.21: nicotinate phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C327 H331 C344 C347 C327 H331 C344 C347
BS02 ZN A H178 D209 D235 H178 D209 D235
BS03 PCP A F134 R137 H138 P177 H178 R233 D235 G270 G289 G290 F134 R137 H138 P177 H178 R233 D235 G270 G289 G290
Gene Ontology
Molecular Function
GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:0004516 nicotinate phosphoribosyltransferase activity
GO:0016740 transferase activity
GO:0016763 pentosyltransferase activity
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0009435 NAD biosynthetic process
GO:0019363 pyridine nucleotide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2i14, PDBe:2i14, PDBj:2i14
PDBsum2i14
PubMed
UniProtQ8TZS9

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