Structure of PDB 2i0j Chain A

Receptor sequence
>2i0jA (length=221) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELV
HMINWAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFA
PNLLLDRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLN
SGVYTFSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQL
LLILSHIRHMSNKGMEHLYSM
3D structure
PDB2i0j Benzopyrans are selective estrogen receptor Beta agonists with novel activity in models of benign prostatic hyperplasia.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I0G A E353 L384 R394 F404 M421 I424 H524 E48 L79 R89 F99 M116 I119 H217 PDBbind-CN: -logKd/Ki=8.57,Ki=2.68nM
BindingDB: Ki=2.7nM,EC50=19.4nM
External links
PDB RCSB:2i0j, PDBe:2i0j, PDBj:2i0j
PDBsum2i0j
PubMed17034120
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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